Butcher Research Group – Discovering novel nematode natural products and exploring their role in chemical communication

Back together again!

First group photo in a long while.

Butcher Group 2023

In front of Scott Family Hall

Feng, et al.

Our new paper came out in Nature Communications on the many genes that contribute to nemamide biosynthesis (doi: 10.1038/s41467-021-24682-9). Congrats Likui, Matt, and Ying!

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Natural Product Discovery

We are using new techniques in comparative metabolomics, activity-guided fractionation, and NMR spectroscopy to identify the chemical structures of new pheromones and hormones from nematodes.

Natural Product Biosynthesis

We are using CRISPR-Cas9, RNAi, comparative metabolomics, stable-isotope labeling, enzyme assays, and X-ray crystallography to discover how nematodes biosynthesize hormones and pheromones.

Natural Product Mechanism

We are using chemical probes, transgenic worm strains, and biological assays to investigate how hormones and pheromones affect the development and behavior of nematodes.